Two American teenagers in search of cheap drugs, trespass into the seedy town of Barrio, Mexico. What they find instead is a disturbed story teller and three tales filled with blood, witches and a cannibalistic taco chef.

In the desert area of Hat Creek, cows are found partially devoured and the farmers believe that a wolf is attacking the cattle. The alcoholic Sheriff Annie Flynn is called by the local farmer Rob Horn to witness the remains of an animal to request reimbursement from the government and for an accident with a tank truck that is blocking the road. However, Annie sooner discovers that an ancient alien creature sent to annihilate life on Earth hundreds of years ago was released by the Indian Kale during an archaeological excavation in the desert. The Indian Caya and a group of travelers stranded in the spot without gas together with Annie and Kale try to find a means to destroy the alien and save mankind.